Fresh analysis suggests that individuals who come off popular slimming jabs like semaglutide or tirzepatide can put back on reduced body mass at a significantly accelerated pace than those who halt conventional diet and exercise programs.
Research printed in a major medical journal shows that while overweight individuals often shed about a fifth of their body weight while on the medication, the weight is regained at an average rate of nearly a kilo each month once they quit.
"People purchasing such treatments need to be cognizant of the risk of rapid rebound weight gain when the medication is stopped," warns expert Dr. Susan Jebb.
This pace of regain suggests a return to pre-treatment mass within about a year and a half.
Analyzing Therapies
The analysis, which looked at 37 of trials involving over 9,000 of patients, contrasted the results of the injectable medications with other pills.
Scientists point out that people who lose weight through lifestyle changes alone usually see a more gradual weight regain—perhaps 100 grams monthly—after stopping.
The Reason for the Rapid Regain
Nutrition scientists suggest the way of the jabs explains the amplified rebound.
GLP-1 drugs mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Artificially providing GLP-1 levels several times higher than normal might result in the body to generate a reduced amount of its own natural hormone, and may also diminish responsiveness to its effects," explained Dr. Adam Collins, a dietetics expert.
"Withdrawal of this GLP-1 'fix' results in appetite is unsuppressed, making overeating a significant risk."
An Ongoing Issue?
The NHS recommend the injections for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
A number of clinicians say that, considering the significant potential of relapse, the therapy is often life-long.
This perspective is echoed by pharmaceutical companies, who say that the findings "underscore the chronic character of excess weight," comparing it to managing conditions like hypertension.
Patient Experiences
People who have stopped the medication describe a powerful return of cravings.
"I experienced something that goes on and you're instantly ravenous," said a patient.
The struggle is worsened if patients have not developed permanent lifestyle or habit changes during therapy.
Widespread Use
Figures indicate that millions of adults in the UK have used weight-loss jabs in the past year, with interest remaining high.
- Use is more common among females compared to males.
- The middle-aged age group shows the greatest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
Ultimately, researchers caution that while these medications are effective tools for shedding pounds, they are not a permanent fix and lasting health benefits relies on integrated behavioural changes.
